The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotyping

被引：212

作者：

Brown, Steve D. M. ^{[1
]}

Moore, Mark W. ^{[2
]}

机构：

[1] MRC Harwell, MRC Mammalian Genet Unit, Didcot OX11 0RD, Oxon, England

[2] NHGRI, Int Mouse Phenotyping Consortium, NIH, Bethesda, MD 20892 USA

来源：

MAMMALIAN GENOME | 2012年 / 23卷 / 9-10期

基金：

英国医学研究理事会;

关键词：

FUNCTIONAL ANNOTATION; RESOURCE; GENOME; EUROPHENOME; MICROSCOPY; MORPHOLOGY; EMPRESS;

D O I：

10.1007/s00335-012-9427-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Determining the function of all mammalian genes remains a major challenge for the biomedical science community in the 21st century. The goal of the International Mouse Phenotyping Consortium (IMPC) over the next 10 years is to undertake broad-based phenotyping of 20,000 mouse genes, providing an unprecedented insight into mammalian gene function. This short article explores the drivers for large-scale mouse phenotyping and provides an overview of the aims and processes involved in IMPC mouse production and phenotyping.

引用

页码：632 / 640

页数：9

共 18 条

[1] Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project [J].

Ayadi, Abdel ;

Birling, Marie-Christine ;

Bottomley, Joanna ;

Bussell, James ;

Fuchs, Helmut ;

Fray, Martin ;

Gailus-Durner, Valerie ;

Greenaway, Simon ;

Houghton, Richard ;

Karp, Natasha ;

Leblanc, Sophie ;

Lengger, Christoph ;

Maier, Holger ;

Mallon, Ann-Marie ;

Marschall, Susan ;

Melvin, David ;

Morgan, Hugh ;

Pavlovic, Guillaume ;

Ryder, Ed ;

Skarnes, William C. ;

Selloum, Mohammed ;

Ramirez-Solis, Ramiro ;

Sorg, Tania ;

Teboul, Lydia ;

Vasseur, Laurent ;

Walling, Alison ;

Weaver, Tom ;

Wells, Sara ;

White, Jacqui K. ;

Bradley, Allan ;

Adams, David J. ;

Steel, Karen P. ;

de Angelis, Martin Hrabe ;

Brown, Steve D. ;

Herault, Yann .

MAMMALIAN GENOME, 2012, 23 (9-10) :600-610

[2] EMPReSS: standardized phenotype screens for functional annotation of the mouse genome [J].

Brown, SDM ;

Chambon, P ;

de Angelis, MH .

NATURE GENETICS, 2005, 37 (11) :1155-1155

[3] Understanding mammalian genetic systems: The challenge of phenotyping in the mouse [J].

Brown, Steve D. M. ;

Hancock, John M. ;

Gates, Hilary .

PLOS GENETICS, 2006, 2 (08) :1131-1137

[4] The Functional Annotation of Mammalian Genomes: The Challenge of Phenotyping [J].

Brown, Steve D. M. ;

Wurst, Wolfgang ;

Kuehn, Ralf ;

Hancock, John M. .

ANNUAL REVIEW OF GENETICS, 2009, 43 :305-333

[5] DEATH BEFORE BIRTH - CLUES FROM GENE KNOCKOUTS AND MUTATIONS [J].

COPP, AJ .

TRENDS IN GENETICS, 1995, 11 (03) :87-93

[6] The Mouse Genome Database (MGD): comprehensive resource for genetics and genomics of the laboratory mouse [J].

Eppig, Janan T. ;

Blake, Judith A. ;

Bult, Carol J. ;

Kadin, James A. ;

Richardson, Joel E. .

NUCLEIC ACIDS RESEARCH, 2012, 40 (D1) :D881-D886

[7] Introducing the German Mouse Clinic:: open access platform for standardized phenotyping [J].

Gailus-Durner, V ;

Fuchs, H ;

Becker, L ;

Bolle, I ;

Brielmeier, M ;

Calzada-Wack, J ;

Evert, R ;

Ehrhardt, N ;

Dalkel, C ;

Franz, TJ ;

Grundner-Culemann, E ;

Hammelbacher, S ;

Hölter, SM ;

Hötzlwimmer, G ;

Horsch, M ;

Javaheri, A ;

Kataydjiev, SV ;

Klempt, M ;

Kling, E ;

Kunder, S ;

Lengger, C ;

Lisse, T ;

Mijalski, T ;

Naton, B ;

Pedersen, V ;

Prehn, C ;

Przemeck, G ;

Racz, I ;

Reinhard, C ;

Reitmeir, P ;

Schneider, I ;

Schrewe, A ;

Steinkamp, R ;

Zybill, C ;

Adamski, J ;

Beckers, J ;

Behrendt, H ;

Favor, J ;

Graw, J ;

Heldmaier, G ;

Höfer, H ;

Ivandic, B ;

Katus, H ;

Kirchhof, P ;

Kiingenspor, M ;

Kopstock, T ;

Lengeling, A ;

Mfitier, W ;

Ohl, F ;

Ollert, M .

NATURE METHODS, 2005, 2 (06) :403-404

[8] PhenomeNET: a whole-phenome approach to disease gene discovery [J].

Hoehndorf, Robert ;

Schofield, Paul N. ;

Gkoutos, Georgios V. .

NUCLEIC ACIDS RESEARCH, 2011, 39 (18) :e119

[9] Optical coherence tomography for live phenotypic analysis of embryonic ocular structures in mouse models [J].

Larina, Irina V. ;

Syed, Saba H. ;

Sudheendran, Narendran ;

Overbeek, Paul A. ;

Dickinson, Mary E. ;

Larin, Kirill V. .

JOURNAL OF BIOMEDICAL OPTICS, 2012, 17 (08)

[10] EuroPhenome and EMPReSS: online mouse phenotyping resource [J].

Mallon, Ann-Marie ;

Blake, Andrew ;

Hancock, John M. .

NUCLEIC ACIDS RESEARCH, 2008, 36 :D715-D718

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