Threat matrix - Low-molecular-weight hyaluronan (HA) as a danger signal

被引：115

作者：

Powell, JD ^{[1
]}

Horton, MR ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

来源：

IMMUNOLOGIC RESEARCH | 2005年 / 31卷 / 03期

关键词：

T cells; hyaluronan; danger theory; TLR; costimulation;

D O I：

10.1385/IR:31:3:207

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Whether or not T cell receptor engagement leads to full activation or tolerance is determined by the context in which the antigen is encountered. Antigen presented by activated APCs in the presence of costimulation leads to full T cell activation, while antigen presented by resting APCs leads to tolerance. Pathogen-associated molecular patterns in the form of toll-like receptor ligands play a critical role In activating APCs and promoting T cell activation. In this review we hypothesize that low-molecular-weight species of the extracellular matrix polymer hyaluronan also performs this function by acting as an endogenous danger signal.

引用

页码：207 / 218

页数：12

共 85 条

[41] CD28/B7 system of T cell costimulation [J].