Preparation and characterization of self-assembled nanoparticles of 6-O-cholesterol-modified chitosan for drug delivery

被引：65

作者：

Chen, Mingmao ^{[1
,2
]}

Liu, Yan ^{[1
,2
]}

Yang, Wenzhi ^{[1
,2
]}

Li, Xuemin ^{[1
,2
]}

Liu, Lingrong ^{[1
,2
]}

Zhou, Zhimin ^{[1
,2
]}

Wang, Yinsong ^{[1
,2
]}

Li, Ruifeng ^{[1
,2
]}

Zhang, Qiqing ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Med Sci, Inst Biomed Engn, Tianjin 300192, Peoples R China

[2] Peking Union Med Coll, Key Lab Biomed Mat Tianjin, Tianjin 300192, Peoples R China

[3] Xiamen Univ, Biomed Engn Res Ctr, Technol Res Ctr Biomed Engn Xiamen City, Key Lab Biomed Engn Fujian Prov, Xiamen 361005, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2011年 / 84卷 / 04期

关键词：

Chitosan; Cholesterol; Phthaloylchitosan; Self-assembled nanoparticles; All-trans retinoic acid; TRANS-RETINOIC ACID; SHELL TYPE NANOPARTICLES; AGGREGATED NANOPARTICLES; PHYSICOCHEMICAL CHARACTERISTICS; HYDROGEL NANOPARTICLE; CONTROLLED-RELEASE; IN-VITRO; WATER; DERIVATIVES; MICELLES;

D O I：

10.1016/j.carbpol.2011.01.012

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

6-O-Cholesterol modified chitosan (O-CHCS) conjugates with succinyl linkages were synthesized through a protection-graft-deprotection method with phthaloylchitosan as an intermediate. O-CHCS conjugates were characterized by Fourier transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (H-1 NMR), and the degrees of substitution (DS) of the cholesterol moiety determined by elemental analysis were 1.7%, 4.0% or 5.9%. O-CHCS self-assembled nanoparticles prepared by the dialysis method displayed the classic "core-shell" structures and their sizes were in the range of 100-240 nm. All-trans retinoic acid (ATRA), as a model drug, was physically entrapped inside O-CHCS self-assembled nanoparticles by the dialysis method. With increasing initial levels of the drug, the drug loading content increased, but the encapsulation efficiency and the particle size decreased. The release profiles in vitro demonstrated that ATRA showed slow sustained released over 72 h, which indicated that O-CHCS self-assembled nanoparticles had the potential to be used as a carrier for hydrophobic drugs. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1244 / 1251

页数：8

共 48 条

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Microscopic structure and thermoresponsiveness of a hydrogel nanoparticle by self-assembly of a hydrophobized polysaccharide [J].