Cytoskeletal changes in cell transformation and tumorigenesis

被引:300
作者
Pawlak, G [1 ]
Helfman, DM [1 ]
机构
[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
关键词
D O I
10.1016/S0959-437X(00)00154-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Research during the past couple of years has provided important new information as to how the actin cytoskeleton contributes to growth control in both normal and transformed cells. The cytoskeleton can no longer be viewed as simply a structural framework playing a role in cell shape and motile events such as cell movement, intracellular transport, contractile-ring formation and chromosome movement. More recent experiments show that the cytoskeleton plays a critical role in the regulation of various cellular processes linked to transformation including proliferation, contact inhibition, anchorage-independent cell growth, and apoptosis.
引用
收藏
页码:41 / 47
页数:7
相关论文
共 84 条
[81]  
Wang FL, 1996, CANCER RES, V56, P3634
[82]   Tyrosine phosphorylation of caldesmon is required for binding to the Shc•Grb2 complex [J].
Wang, Z ;
Danielsen, AJ ;
Maihle, NJ ;
McManus, MJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (47) :33807-33813
[83]   Cytoskeletal disruption accelerates caspase-3 activation and alters the intracellular membrane reorganization in DNA damage-induced apoptosis [J].
Yamazaki, Y ;
Tsuruga, M ;
Zhou, D ;
Fujita, Y ;
Shang, XY ;
Dang, Y ;
Kawasaki, K ;
Oka, S .
EXPERIMENTAL CELL RESEARCH, 2000, 259 (01) :64-78
[84]   Lysophosphatidic acid and microtubule-destabilizing agents stimulate fibronectin matrix assembly through Rho-dependent actin stress fiber formation and cell contraction [J].
Zhang, QH ;
Magnusson, MK ;
Mosher, DF .
MOLECULAR BIOLOGY OF THE CELL, 1997, 8 (08) :1415-1425