Mechanisms Underlying Bone Loss Associated with Gut Inflammation

被引:24
作者
Ke, Ke [1 ]
Arra, Manoj [1 ]
Abu-Amer, Yousef [1 ,2 ]
机构
[1] Washington Univ, Sch Med, Dept Orthopaed Surg & Cell Biol & Physiol, St Louis, MI 63110 USA
[2] Shriners Hosp Children, St Louis, MI 63110 USA
关键词
gut inflammation; mucosal immunity; bone loss; risk factors; animal models; osteoclasts; VITAMIN-D-RECEPTOR; NF-KAPPA-B; TIGHT JUNCTION PERMEABILITY; INTESTINAL EPITHELIAL-CELLS; GENOME-WIDE ASSOCIATION; BOWEL-DISEASE; CROHNS-DISEASE; EXTRAINTESTINAL MANIFESTATIONS; TAUROURSODEOXYCHOLIC ACID; ANKYLOSING-SPONDYLITIS;
D O I
10.3390/ijms20246323
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
Patients with gastrointestinal diseases frequently suffer from skeletal abnormality, characterized by reduced bone mineral density, increased fracture risk, and/or joint inflammation. This pathological process is characterized by altered immune cell activity and elevated inflammatory cytokines in the bone marrow microenvironment due to disrupted gut immune response. Gastrointestinal disease is recognized as an immune malfunction driven by multiple factors, including cytokines and signaling molecules. However, the mechanism by which intestinal inflammation magnified by gut-residing actors stimulates bone loss remains to be elucidated. In this article, we discuss the main risk factors potentially contributing to intestinal disease-associated bone loss, and summarize current animal models, illustrating gut-bone axis to bridge the gap between intestinal inflammation and skeletal disease.
引用
收藏
页数:29
相关论文
共 204 条
[1]
Serum vitamin D and colonic vitamin D receptor in inflammatory bowel disease [J].
Abreu-Delgado, Yamilka ;
Isidro, Raymond A. ;
Torres, Esther A. ;
Gonzalez, Alexandra ;
Cruz, Myrella L. ;
Isidro, Angel A. ;
Gonzalez-Keelan, Carmen I. ;
Medero, Priscilla ;
Appleyard, Caroline B. .
WORLD JOURNAL OF GASTROENTEROLOGY, 2016, 22 (13) :3581-3591
[2]
NF-κB signaling and bone resorption [J].
Abu-Amer, Y. .
OSTEOPOROSIS INTERNATIONAL, 2013, 24 (09) :2377-2386
[3]
Paneth cells as a site of origin for intestinal inflammation [J].
Adolph, Timon E. ;
Tomczak, Michal F. ;
Niederreiter, Lukas ;
Ko, Hyun-Jeong ;
Boeck, Janne ;
Martinez-Naves, Eduardo ;
Glickman, Jonathan N. ;
Tschurtschenthaler, Markus ;
Hartwig, John ;
Hosomi, Shuhei ;
Flak, Magdalena B. ;
Cusick, Jennifer L. ;
Kohno, Kenji ;
Iwawaki, Takao ;
Billmann-Born, Susanne ;
Raine, Tim ;
Bharti, Richa ;
Lucius, Ralph ;
Kweon, Mi-Na ;
Marciniak, Stefan J. ;
Choi, Augustine ;
Hagen, Susan J. ;
Schreiber, Stefan ;
Rosenstiel, Philip ;
Kaser, Arthur ;
Blumberg, Richard S. .
NATURE, 2013, 503 (7475) :272-+
[4]
Association of vitamin D receptor gene polymorphism (TaqI and Apa1) with bone mineral density in North Indian postmenopausal women [J].
Ahmad, Israr ;
Jafar, Tabrez ;
Mahdi, Farzana ;
Ameta, Keerti ;
Arshad, Md. ;
Das, Siddharth Kumar ;
Waliullah, Shah ;
Rizvi, Imran ;
Mahdi, Abbas Ali .
GENE, 2018, 659 :123-127
[5]
TNF-α Modulation of Intestinal Tight Junction Permeability Is Mediated by NIK/IKK-α Axis Activation of the Canonical NF-κB Pathway [J].
Al-Sadi, Rana ;
Guo, Shuhong ;
Ye, Dongmei ;
Rawat, Manmeet ;
Ma, Thomas Y. .
AMERICAN JOURNAL OF PATHOLOGY, 2016, 186 (05) :1151-1165
[6]
IL-1β-Induced Increase in Intestinal Epithelial Tight Junction Permeability Is Mediated by MEKK-1 Activation of Canonical NF-κB Pathway [J].
Al-Sadi, Rana ;
Ye, Dongmei ;
Said, Hamid M. ;
Ma, Thomas Y. .
AMERICAN JOURNAL OF PATHOLOGY, 2010, 177 (05) :2310-2322
[7]
IL-1β causes an increase in intestinal epithelial tight junction permeability [J].
Al-Sadi, Rana M. ;
Ma, Thomas Y. .
JOURNAL OF IMMUNOLOGY, 2007, 178 (07) :4641-4649
[8]
Osteoporosis in Inflammatory Bowel Disease [J].
Ali, Tauseef ;
Lam, David ;
Bronze, Michael S. ;
Humphrey, Mary Beth .
AMERICAN JOURNAL OF MEDICINE, 2009, 122 (07) :599-604
[9]
The Intestinal Epithelium: Central Coordinator of Mucosal Immunity [J].
Allaire, Joannie M. ;
Crowley, Shauna M. ;
Law, Hong T. ;
Chang, Sun-Young ;
Ko, Hyun-Jeong ;
Vallance, Bruce A. .
TRENDS IN IMMUNOLOGY, 2018, 39 (09) :677-696
[10]
Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: Formal histomorphometric and biomechanical analyses [J].
Amling, M ;
Priemel, M ;
Holzmann, T ;
Chapin, K ;
Rueger, JM ;
Baron, R ;
Demay, MB .
ENDOCRINOLOGY, 1999, 140 (11) :4982-4987