Fluorine (19F) MRS and MRI in biomedicine

被引：415

作者：

Ruiz-Cabello, Jesus ^{[1
,2
,3
,4
,5
]}

Barnett, Brad P. ^{[1
,2
,3
]}

Bottomley, Paul A. ^{[1
]}

Bulte, Jeff W. M. ^{[1
,2
,3
,6
,7
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Vasc Biol Program, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Cellular Imaging Sect, Baltimore, MD 21205 USA

[4] Univ Complutense, Inst Funct Studies, NMR Grp, E-28040 Madrid, Spain

[5] CIBERES, Madrid, Spain

[6] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA

[7] Johns Hopkins Univ, Sch Med, Dept Chem & Biomol Engn, Baltimore, MD 21205 USA

来源：

NMR IN BIOMEDICINE | 2011年 / 24卷 / 02期

关键词：

perfluorocarbon; MR contrast agent; lung ventilation; oxygen measurement; molecular imaging; cellular imaging; MAGNETIC-RESONANCE-SPECTROSCOPY; IN-VIVO; CONTRAST AGENT; RADIATION-THERAPY; INTRATUMORAL PHARMACOKINETICS; PERFLUOROCARBON EMULSIONS; INVERSION-RECOVERY; LIQUID VENTILATION; BRAIN FLUVOXAMINE; NMR-SPECTROSCOPY;

D O I：

10.1002/nbm.1570

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Shortly after the introduction of H-1 MRI, fluorinated molecules were tested as MR-detectable tracers or contrast agents. Many fluorinated compounds, which are nontoxic and chemically inert, are now being used in a broad range of biomedical applications, including anesthetics, chemotherapeutic agents, and molecules with high oxygen solubility for respiration and blood substitution. These compounds can be monitored by fluorine (F-19) MRI and/or MRS, providing a noninvasive means to interrogate associated functions in biological systems. As a result of the lack of endogenous fluorine in living organisms, F-19 MRI of 'hotspots' of targeted fluorinated contrast agents has recently opened up new research avenues in molecular and cellular imaging. This includes the specific targeting and imaging of cellular surface epitopes, as well as MRI cell tracking of endogenous macrophages, injected immune cells and stem cell transplants. Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：114 / 129

页数：16

共 142 条

[1] Quantitative mapping of ventilation-perfusion ratios in lungs by 19F MR imaging of T1 of inert fluorinated gases [J].