The embryonic develops by human choriocapillaris hemo-vasculogenesis

被引：40

作者：

Hasegawa, Takuya ^{[1
]}

McLeod, D. Scott ^{[1
]}

Bhutto, Imran A. ^{[1
]}

Prow, Tarl ^{[1
]}

Merges, Carol A. ^{[1
]}

Grebe, Rhonda ^{[1
]}

Lutty, Gerard A. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Wilmer Ophthalmol Inst, Baltimore, MD 21205 USA

来源：

DEVELOPMENTAL DYNAMICS | 2007年 / 236卷 / 08期

关键词：

choroids; hemo-vasculogenesis; hemangioblasts; angiogenesis; vascular precursors;

D O I：

10.1002/dvdy.21231

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The purpose of this study was to characterize normal human choroidal vascular development from 6-23 weeks gestation (WG). Markers of endothelial cells (EC) (CD34, CD31, vWf), angioblasts and EC (CD39), leukocytes (CD45), erythroblasts (epsilon chain of hemoglobin, Hb-e), proliferating cells (Ki67), and VEGFR2 were employed. At 6-7 WG, many erythroblasts were observed within islands of precursor cells in the choriocapillaris layer and others were independent from the islands. Many erythroblasts (Hb-epsilon(+)) were also positive for EC markers and/or VEGFR-2. By 8-12 WG, most of the Hb-epsilon cells had disappeared and vascular lumens became apparent. At 14-23 WG, some EC were proliferating on the seleral side of choriocapillaris in association with forming deeper vessels. In conclusion, embryonic choriocapillaris appears to form initially by hemo-vasculogenesis (blood vessels and blood cells form simultaneously from common precursors) while angiogenesis appears to be the mode of intermediate and large choroidal vessel development in the fetus.

引用

页码：2089 / 2100

页数：12

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