Comparison of a T cell clone and of T cells from a TCR transgenic mouse: TCR transgenic T cells specific for self-antigen are atypical

被引：24

作者：

Dobbs, CM

Haskins, K

机构：

[1] Univ Colorado, Hlth Sci Ctr, Dept Immunol, Denver, CO 80262 USA

[2] Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA

来源：

JOURNAL OF IMMUNOLOGY | 2001年 / 166卷 / 04期

关键词：

D O I：

10.4049/jimmunol.166.4.2495

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It has been widely assumed that T cells from TCR-transgenic (Tg) mice better represent the behavior of T cells from normal mice than do in vitro cultures of T cell clones. We have found that autoreactive T cells arising in the presumably more physiological environment of the BDC-2.5 TCR-Tg mouse, despite being apparently "naive" in surface phenotype, are highly activated functionally and do not resemble CD4(+) T cells from a spontaneously diabetic nonobese diabetic (NOD) mouse or the NOD-derived, diabetogenic CD4+ T cell clone of origin, BDC-2.5. Our results suggest that autoreactive T cells cloned from the spontaneously diabetic NOD mouse more closely resemble effector T cells arising during the natural disease process. The Journal of Immunology, 2001, 166: 2495-2504.

引用

页码：2495 / 2504

页数：10

共 63 条

[31] ISOLATION OF A CA-DEPENDENT ERYTHROLYTIC PROTEIN (PERFORIN) FROM CYTOTOXIC LYMPHOCYTES-T
ISHIURA, S
ANRAKU, H
KAMO, I
KOIZUMI, H
ARAHATA, K
SUGITA, H
[J]. JOURNAL OF BIOCHEMISTRY, 1987, 102 (01) : 9 - 12
[32] FOLLOWING A DIABETOGENIC T-CELL FROM GENESIS THROUGH PATHOGENESIS
KATZ, JD
WANG, B
HASKINS, K
BENOIST, C
MATHIS, D
[J]. CELL, 1993, 74 (06) : 1089 - 1100
[33] THE MURINE AUTOIMMUNE DIABETES MODEL - NOD AND RELATED STRAINS
KIKUTANI, H
MAKINO, S
[J]. ADVANCES IN IMMUNOLOGY, 1992, 51 : 285 - 322
[34] beta cell apoptosis in T cell-mediated autoimmune diabetes
Kurrer, MO
Pakala, SV
Hanson, HL
Katz, JD
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (01) : 213 - 218
[35] HIGH-INCIDENCE OF SPONTANEOUS AUTOIMMUNE ENCEPHALOMYELITIS IN IMMUNODEFICIENT ANTIMYELIN BASIC-PROTEIN T-CELL RECEPTOR TRANSGENIC MICE
LAFAILLE, JJ
NAGASHIMA, K
KATSUKI, M
TONEGAWA, S
[J]. CELL, 1994, 78 (03) : 399 - 408
[36] THE DIFFERENTIAL EXPRESSION OF HOMING AND ADHESION MOLECULES ON VIRGIN AND MEMORY T-CELLS IN THE MOUSE
LEE, WT
VITETTA, ES
[J]. CELLULAR IMMUNOLOGY, 1991, 132 (01) : 215 - 222
[37] LEITER EH, 1987, J IMMUNOL, V138, P3224
[38] LACK OF L-SELECTIN EXPRESSION BY CELLS TRANSFERRING DIABETES IN NOD MICE - INSIGHTS INTO THE MECHANISMS INVOLVED IN DIABETES PREVENTION BY MEL-14 ANTIBODY TREATMENT
LEPAULT, F
GAGNERAULT, MC
FAVEEUW, C
BAZIN, H
BOITARD, C
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (06) : 1502 - 1507
[39] LONG-TERM ABROGATION OF AUTOIMMUNE DIABETES IN NONOBESE DIABETIC MICE BY IMMUNOTHERAPY WITH ANTILYMPHOCYTE-SERUM
MAKI, T
ICHIKAWA, T
BLANCO, R
PORTER, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (08) : 3434 - 3438
[40] Adhesion molecules in autoimmune disease
McMurray, RW
[J]. SEMINARS IN ARTHRITIS AND RHEUMATISM, 1996, 25 (04) : 215 - 233

← 1 2 3 4 5 6 7 →