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Human neurodegenerative disease modeling using Drosophila

被引：124
作者：
Bonini, NM
Fortini, ME
机构：
[1] Univ Penn, Howard Hughes Med Inst, Dept Biol, Philadelphia, PA 19104 USA
[2] NCI, Div Basic Sci, Ft Detrick, MD 21702 USA
来源：
ANNUAL REVIEW OF NEUROSCIENCE | 2003年 / 26卷
关键词：
polyglutamine; tau; presenilin; Alzheimer's disease; Parkinson's disease;
D O I：
10.1146/annurev.neuro.26.041002.131425
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A number of approaches have been taken to recreate and to study the role of genes associated with human neurodegenerative diseases in the model organism Drosophila. These studies encompass the polyglutamine diseases, Parkinson's disease, Alzheimer's disease, and tau-associated pathologies. The findings highlight Drosophila as an important model system in which to study the fundamental pathways influenced by these genes and have led to new insights into aspects of pathogenesis and modifier mechanisms.
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页码：627 / 656
页数：34
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