Process of folding proteins into membranes: Challenges and progress

被引：76

作者：

Stanley, Ann Marie ^{[1
]}

Fleming, Karen G. ^{[1
]}

机构：

[1] Johns Hopkins Univ, TC Jenkins Dept Biophys, Baltimore, MD 21218 USA

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2008年 / 469卷 / 01期

基金：

美国国家科学基金会;

关键词：

membrane protein; thermodynamics; protein folding;

D O I：

10.1016/j.abb.2007.09.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Just 25 years ago the Anfinsen thermodynamic hypothesis was shown to be valid for membrane proteins. Despite the complex biological machinery required for their in vivo assembly and in face of the chemically heterogeneous, anisotropic nature of their biological lipid bilaver "solvent", the evidence continues to suggest that membrane proteins are equilibrium structures. The progress in finding conditions in vitro to investigate the physical origins of their stabilities is the focus of this article. We catalogue in vitro folding studies in detergent micelles and in lipid bilayers. We consider the unique technical obstacles to folding studies of membrane proteins, and we highlight the progress that has been made in quantitative descriptions of membrane protein stability. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：46 / 66

页数：21

共 125 条

[101] Expression of porin from Rhadopseudomonas blastica in Escherichia coli inclusion bodies and folding into exact native structure [J].

Schmid, B ;

Kromer, M ;

Schulz, GE .

FEBS LETTERS, 1996, 381 (1-2) :111-114

[102] MAJOR PROTEINS OF ESCHERICHIA-COLI OUTER CELL-ENVELOPE MEMBRANE - INTERACTION OF PROTEIN-IISTAR WITH LIPOPOLYSACCHARIDE [J].

SCHWEIZER, M ;

HINDENNACH, I ;

GARTEN, W ;

HENNING, U .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1978, 82 (01) :211-217

[103] Correct folding of the β-barrel of the human membrane protein VDAC requires a lipid bilayer [J].

Shanmugavadivu, Baladhandapani ;

Apell, Hans-Juergen ;

Meins, Thomas ;

Zeth, Kornelius ;

Kleinschmidt, Joerg H. .

JOURNAL OF MOLECULAR BIOLOGY, 2007, 368 (01) :66-78

[104] THERMAL TRANSITIONS IN THE PURPLE MEMBRANE FROM HALOBACTERIUM-HALOBIUM [J].

SHNYROV, VL ;

MATEO, PL .

FEBS LETTERS, 1993, 324 (02) :237-240

[105] Lipoprotein SmpA is a component of the YaeT complex that assembles outer membrane proteins in Escherichia coli [J].

Sklar, Joseph G. ;

Wu, Tao ;

Gronenberg, Luisa S. ;

Malinverni, Juliana C. ;

Kahne, Daniel ;

Silhavy, Thomas J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (15) :6400-6405

[106] MEMBRANE TOPOLOGY OF ESCHERICHIA-COLI DIACYLGLYCEROL KINASE [J].

SMITH, RL ;

OTOOLE, JF ;

MAGUIRE, ME ;

SANDERS, CR .

JOURNAL OF BACTERIOLOGY, 1994, 176 (17) :5459-5465

[107]

STECK T L, 1973, Journal of Supramolecular Structure, V1, P220, DOI 10.1002/jss.400010307

[108] Structure of a biologically active fragment of human serum apolipoprotein C-II in the presence of sodium dodecyl sulfate and dodecylphosphocholine [J].

Storjohann, R ;

Rozek, A ;

Sparrow, JT ;

Cushley, RJ .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2000, 1486 (2-3) :253-264

[109]

SURREY T, 1995, J BIOL CHEM, V270, P28199

[110] Folding and membrane insertion of the trimeric beta-barrel protein OmpF [J].

Surrey, T ;

Schmid, A ;

Jahnig, F .

BIOCHEMISTRY, 1996, 35 (07) :2283-2288

← 4 5 6 7 8 9 10 11 12 13 →