Diketopiperazines from Marine Organisms

被引：138

作者：

Huang, Riming ^{[1
,2
]}

Zhou, Xuefeng ^{[1
]}

Xu, Tunhai ^{[3
]}

Yang, Xianwen ^{[1
]}

Liu, Yonghong ^{[1
]}

机构：

[1] Chinese Acad Sci, S China Sea Inst Oceanol, Res Ctr Marine Microbes,Guangdong Key Lab Marine, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China

[2] Chinese Acad Sci, S China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China

[3] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2010年 / 7卷 / 12期

基金：

中国国家自然科学基金;

关键词：

PRENYLATED INDOLE ALKALOIDS; CYTOTOXIC METABOLITES; A-D; PEPTIDE SYNTHETASE; CYCLIC DIPEPTIDES; TRYPROSTATIN-B; GENE CLUSTERS; FUNGUS; SPONGE; BIOSYNTHESIS;

D O I：

10.1002/cbdv.200900211

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diketopiperazines (DKPs), which are cyclic dipeptides, have been detected in a variety of natural resources. Recently, the interest in these compounds increased significantly because of their remarkable bioactivity. This review deals with the chemical structures, biosynthetic pathways, and biological activities of DKPs from marine microorganisms, sponges, sea stars, tunicates (ascidians), and red algae. The literature has been covered up to December 2008, and a total 124 DKPs from 104 publications have been discussed and reviewed. Some of these compounds have been found to possess various bioactivities including cytotoxicity, and antibacterial, antifungal, antifouling, plant-growth regulatory, and other activities.

引用

页码：2809 / 2829

页数：21

共 103 条

[1] CHEMISTRY OF THE CYTOTOXIC PRINCIPLES OF THE MARINE FUNGUS LIGNINCOLA-LAEVIS [J].