Administration of 17α-ethinylestradiol during pregnancy elicits modifications of maternal behavior and emotional alteration of the offspring in the rat

被引：23

作者：

Arabo, A ^{[1
]}

Lefebvre, M ^{[1
]}

Fermanel, M ^{[1
]}

Caston, J ^{[1
]}

机构：

[1] Univ Rouen, Fac Sci, UPRES, EA 1780, F-76821 Mont St Aignan, France

来源：

DEVELOPMENTAL BRAIN RESEARCH | 2005年 / 156卷 / 01期

关键词：

ethinylestradiol; development; maternal behavior; postnatal maturation; anxiety depression; rat;

D O I：

10.1016/j.devbrainres.2005.02.003

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Intraperitoneal administration of 17 alpha-ethinylestradiol (15 mu g.kg(-1)) in pregnant rats, every day from day 9 to day 14 of pregnancy, elicited a high percentage of abortions. Quantification of maternal behavior showed that treated dams took better care of their pups than control dams, injected with the vehicle only, did. Postnatal reflexes, which reflect maturational rate, were established more promptly in the offspring of treated darns than in the offspring of control dams. However, when adult, the rats born from treated darns developed anxiety- and depressive-like behaviors. All these results are explained by the effects of the exogenous estrogen on the developing brain of the fetuses. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：93 / 103

页数：11

共 82 条

[21] REFLEX-ONTOGENY AND BEHAVIOURAL DEVELOPMENT OF MOUSE [J].

FOX, WM .

ANIMAL BEHAVIOUR, 1965, 13 (2-3) :234-&

[22]

FRIEDCASSORLA M, 1987, J REPROD MED, V32, P847

[23] EVIDENCE THAT LONG-TERM ESTROGEN-TREATMENT DISRUPTS OPIOID INVOLVEMENT IN THE INDUCTION OF PITUITARY LH SURGE [J].

FUENTES, M ;

SAHU, A ;

KALRA, SP .

BRAIN RESEARCH, 1992, 583 (1-2) :183-188

[24] Analysis of mouse plus-maze behavior modulated by ovarian steroids [J].

Galeeva, A ;

Tuohimaa, P .

BEHAVIOURAL BRAIN RESEARCH, 2001, 119 (01) :41-47

[25] GONADAL-STEROIDS AS PROMOTERS OF NEURO-GLIAL PLASTICITY [J].

GARCIASEGURA, LM ;

CHOWEN, JA ;

DUENAS, M ;

TORRESALEMAN, I ;

NAFTOLIN, F .

PSYCHONEUROENDOCRINOLOGY, 1994, 19 (5-7) :445-453

[26] GONADAL-HORMONES AS PROMOTERS OF STRUCTURAL SYNAPTIC PLASTICITY - CELLULAR MECHANISMS [J].

GARCIASEGURA, LM ;

CHOWEN, JA ;

PARDUCZ, A ;

NAFTOLIN, F .

PROGRESS IN NEUROBIOLOGY, 1994, 44 (03) :279-&

[27]

Geary N, 1998, Medscape Womens Health, V3, P3

[28] Effect of diethylstilbestrol on reproductive function [J].

Goldberg, JM ;

Falcone, T .

FERTILITY AND STERILITY, 1999, 72 (01) :1-7

[29] ESTRADIOL ACTS VIA THE ESTROGEN-RECEPTOR IN THE SEXUAL-DIFFERENTIATION OF THE RAT-BRAIN, BUT WHAT DOES THIS COMPLEX DO [J].

GORSKI, RA .

ENDOCRINOLOGY, 1993, 133 (02) :431-432

[30]

GRIEBEL G, 1993, BEHAV PHARMACOL, V4, P637

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