Treadmill and wheel exercise protect against JNK/NF-κB induced inflammation in experimental models of knee osteoarthritis

被引：23

作者：

Chen, Liang ^{[1
]}

Lou, Yiting ^{[1
]}

Pan, Zheqiang ^{[1
]}

Cao, Xia ^{[1
]}

Zhang, Leyong ^{[1
]}

Zhu, Chang ^{[2
]}

Liang, Jinxi ^{[1
]}

机构：

[1] Hangzhou Med Coll, Dept Orthoped, Linan Peoples Hosp, Hangzhou 311300, Zhejiang, Peoples R China

[2] Hangzhou Med Coll, Dept Rehabil Med, Linan Peoples Hosp, Hangzhou 311300, Zhejiang, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2020年 / 523卷 / 01期

关键词：

Knee osteoarthritis; JNK/NF-kappa B; Treadmill; Wheel exercise; CHONDROCYTES; MANAGEMENT; APOPTOSIS; MAPK; RATS;

D O I：

10.1016/j.bbrc.2019.12.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Osteoarthritis (OA) remains a challenge for clinicians and effective treatments are lacking. In this study, we investigated JNK/NF-kappa B signaling in knee OA patients. Rats were used to establish an OA model and were divided into six groups; (1) Control (sterile saline injection only); (2) Controls with treadmill exercise (treadmill); (3) Controls with wheel exercise (wheel); (4) OA (MIA injection); (5) OA with treadmill exercise (OA + treadmill); and (6) OA with wheel exercise (OA + wheel). The results showed that, compared to the OA group, the OA + treadmill and OA + wheel groups had lower levels of IL-1 beta, IL-6 and TNF-alpha, and similar levels of p-P65, p-JNK, and P-l kappa B alpha. Furthermore, treatment with the JNK agonist anisomycin enhanced the damage to the joint cartilage and increased the levels of IL-1 beta, IL-6 and TNF-alpha. Taken together, these data suggest that treadmill and wheel exercise protect against inflammation through the regulation of JNK/NF-kappa B signaling in experimental models of knee OA. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：117 / 122

页数：6

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