The zebrafish Nodal signal Squint functions as a morphogen

被引:241
作者
Chen, Y
Schier, AF [1 ]
机构
[1] NYU, Sch Med, Skirball Inst Biomol Med, Dev Genet Program, New York, NY 10016 USA
[2] NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA
关键词
D O I
10.1038/35079121
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 [理学]; 0710 [生物学]; 09 [农学];
摘要
Secreted morphogens induce distinct cellular responses in a concentration-dependent manner and act directly at a distance(1-7). The existence of morphogens during mesoderm induction and patterning in vertebrates has been highly controversial, and it remains unknown whether endogenous mesoderm inducers act directly as morphogens(8-10), function locally(9) or act through relay mechanisms(11-12). Here we test the morphogen properties of Cyclops and Squint-two Nodal-related transforming growth factor-beta signals required for mesoderm formation and patterning in zebrafish(13-16). Whereas different levels of both Squint and Cyclops can induce different downstream genes(14,17-19), we rnd that only Squint can function directly at a distance. These results indicate that Squint acts as a secreted morphogen that does not require a relay mechanism.
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收藏
页码:607 / 610
页数:4
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