The heart SNPs a beat: Polymorphisms in candidate genes for cardiovascular disease

被引：27

作者：

Daley, GQ ^{[1
]}

Cargill, M ^{[1
]}

机构：

[1] MIT, Whitehead Inst Biomed Res, Ctr Genome Res, Cambridge, MA USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2001年 / 11卷 / 02期

关键词：

D O I：

10.1016/S1050-1738(01)00087-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several environmental risk factors of cardiovascular disease are well established, but genetic risk alleles contributing to the disease ill the general population are hotly debated. New strategies focusing Oil polymorphism discovery, in candidate disease genes followed by tests of association to genes across the genome offer a pioneering approach to identifying risk alleles. Several hundred candidate genes for cardiovascular disease have been screened for common polymorphisms and these variants may provide susceptibility alleles which largely contribute to risk of cardiovascular disease ill the general population. However, the impact of common susceptibility alleles for disease management will depend oil many years of future investigation. (Trends Cardiovasc Med 2001;11:60-66). (C) 2001 Elsevier Science Inc.

引用

页码：60 / 66

页数：7

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