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Kinetics of elimination and distribution in blood and liver of biocompatible ferrofluids based on Fe3O4 nanoparticles:: An EPR and XRF study
被引:24
作者:
Gamarra, L. F.
[1
,2
]
Pontuschka, W. M.
[2
]
Amaro, E.
[1
,3
]
Costa-Filho, A. J.
[7
]
Brito, G. E. S.
[2
]
Vieira, E. D.
[7
]
Carneiro, S. M.
[4
]
Escriba, D. M.
[2
]
Falleiros, A. M. F.
[5
]
Salvador, V. L.
[6
]
机构:
[1] Hosp Israelita Albert Einstein, Inst Ensino Pesquisa, BR-05651901 Sao Paulo, Brazil
[2] Univ Sao Paulo, Inst Fis, BR-05315970 Sao Paulo, Brazil
[3] Univ Sao Paulo, Fac Med, Inst Radiol, BR-05403001 Sao Paulo, Brazil
[4] Inst Butantan, Lab Biol Celular, BR-05503900 Sao Paulo, Brazil
[5] Univ Estadual Londrina, Ctr Ciencias Biol, BR-86051990 Londrina, Brazil
[6] IPEN CNEN SP, Ctr Aplicacoes & Lasers, BR-05508000 Sao Paulo, Brazil
[7] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, Brazil
来源:
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS
|
2008年
/
28卷
/
04期
关键词:
EPR;
XRF;
ferroffuid;
endorem;
biodistribution;
nanoparticle;
D O I:
10.1016/j.msec.2007.06.005
中图分类号:
T [工业技术];
学科分类号:
08 ;
摘要:
In this study, we evaluated the biodistribution and the elimination kinetics of a biocompatible magnetic fluid, Endorem (TM), based on dextrancoated Fe3O4 nanoparticles endovenously injected into Winstar rats. The iron content in blood and liver samples was recorded using electron paramagnetic resonance (EPR) and X-ray fluorescence (XRF) techniques. The EPR line intensity at g=2.1 was found to be proportional to the concentration of magnetic nanoparticles and the best temperature for spectra acquisition was 298 K. Both EPR and XRF analysis indicated that the maximum concentration of iron in the liver occurred 95 min after the ferrofluid administration. The half-life of the magnetic nanoparticles (MNP) in the blood was (11.6 +/- 0.6) min measured by EPR and (12.6 +/- 0.6) min determined by XRF. These results indicate that both EPR and XRF are very useful and appropriate techniques for the study of kinetics of ferrofluid elimination and biodistribution after its administration into the organism. (c) 2007 Elsevier B.V. All rights reserved.
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页码:519 / 525
页数:7
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