Inhibition of aldose reductase and anti-cataract action of trans-anethole isolated from Foeniculum vulgare Mill. fruits

被引：50

作者：

Dongare, Vandana ^{[1
]}

Kulkarni, Chaitanya ^{[1
]}

Kondawar, Manish ^{[2
]}

Magdum, Chandrakant ^{[2
]}

Haldavnekar, Vivek ^{[3
]}

Arvindekar, Akalpita ^{[1
]}

机构：

[1] Shivaji Univ, Dept Biochem, Kolhapur 416004, Maharashtra, India

[2] Appasaheb Birnale Coll Pharm, Sangli 416416, Maharashtra, India

[3] Ayurveda Clin, Kolhapur 416008, Maharashtra, India

来源：

FOOD CHEMISTRY | 2012年 / 132卷 / 01期

关键词：

Trans-anethole; Aldose reductase inhibitor; Foeniculum vulgare; Anti-cataract; Antidiabetic; OXIDATIVE STRESS; DIABETIC COMPLICATIONS; ANTIOXIDANT ACTIVITY; POLYOL PATHWAY; EPALRESTAT; GLYCATION;

D O I：

10.1016/j.foodchem.2011.11.005

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Foeniculum vulgare fruits are routinely consumed for their carminative and mouth freshening effect. The plant was evaluated for aldose reductase inhibition and anti-diabetic action. Bioguided fractionation using silica gel column chromatography, HPLC, and GC-MS analysis revealed trans-anethole as the bioactive constituent possessing potent aldose reductase inhibitory action, with an IC50 value of 3.8 mu g/ml. Prolonged treatment with the pet ether fraction of the F. vulgare distillate demonstrated improvement in blood glucose, lipid profile, glycated haemoglobin and other parameters in streptozotocin-induced diabetic rats. Trans-anethole could effectively show anti-cataract activity through the increase in soluble lens protein, reduced glutathione, catalase and SOD activity on in vitro incubation of the eye lens with 55 mM glucose. Trans-anethole demonstrated noncompetitive to mixed type of inhibition of lens aldose reductase using Lineweaver Burk plot. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：385 / 390

页数：6

共 32 条

[1]

[Anonymous], 1974, Catalase. Methods Enzym. Anal., DOI DOI 10.1016/B978-0-12-091302-2.50032-3

[2]

Role of oxidative stress in diabetic complications - A new perspective on an old paradigm [J].