Analysis of patients treated with living pig tissue for evidence of infection by porcine endogenous retroviruses

被引：20

作者：

Cunningham, DA ^{[1
]}

Herring, C ^{[1
]}

Fernández-Suárez, XM ^{[1
]}

Whittam, AJ ^{[1
]}

Paradis, K ^{[1
]}

Langford, GA ^{[1
]}

机构：

[1] Imutran Ltd, Cambridge CB2 2YP, England

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2001年 / 11卷 / 05期

关键词：

D O I：

10.1016/S1050-1738(01)00104-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The use of pigs as a source of cells and organs for transplantation has the potential to reduce the cur-rent chronic shortage of organs for the treatment of many end-stage diseases. The risk of transmission of infectious agents across the species bat-tier (zoonoses) has to be assessed. Many such agents can be eliminated from the pig herd. However, porcine endogenous retroviruses, which are carried within the pig genome, are not easily eliminated. They can infect primary and immortalized human cells in vitro, but to date no evidence for in vivo infection has been found in retrospective studies of humans exposed to viable porcine cells. Small-scale clinical trials using porcine cells for the treatment of Parkinson and Huntington's disease are currently in progress. The prospective monitoring of these patients in conjunction with further research into the biology of this virus will help address safety issues. (C) 2001, Elsevier Science Inc.

引用

页码：190 / 196

页数：7

共 61 条

[1] ENDOGENOUS TYPE-C RNA VIRUSES OF MAMMALIAN-CELLS [J].