Resting-state functional connectivity of the rat brain

被引：162

作者：

Pawela, Christopher P. ^{[1
]}

Biswal, Bharat B. ^{[2
]}

Cho, Younghoon R. ^{[3
]}

Kao, Dennis S. ^{[3
]}

Li, Rupeng ^{[1
]}

Jones, Seth R. ^{[3
]}

Schulte, Marie L. ^{[4
]}

Matloub, Hani S. ^{[3
]}

Hudetz, Anthony G. ^{[4
]}

Hyde, James S. ^{[1
]}

机构：

[1] Med Coll Wisconsin, Dept Biophys, Milwaukee, WI 53226 USA

[2] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Radiol, Newark, NJ 07103 USA

[3] Med Coll Wisconsin, Dept Plast Surg, Milwaukee, WI 53226 USA

[4] Med Coll Wisconsin, Dept Anesthesiol, Milwaukee, WI 53226 USA

来源：

MAGNETIC RESONANCE IN MEDICINE | 2008年 / 59卷 / 05期

关键词：

BOLD resting-state signal; rat fMRI; visual system; sensorimotor system; functional connectivity MRI (fcMRI);

D O I：

10.1002/mrm.21524

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

ations in blood oxygen level dependent (BOLD) MRI contrast at 9.4T in lightly anesthetized resting rat brain are formed, and correlation coefficients between time course pairs are interpreted as measures of connectivity. A hierarchy of regional pairwise correlation coefficients (RPCCs) is observed, with the highest values found in the thalamus and cortex, both intra- and interhemisphere, and lower values between the cortex and thalamus. Independent sensory networks are distinguished by two methods: data driven, where task activation defines regions of interest (ROI), and hypothesis driven, where regions are defined by the rat histological atlas. Success in these studies is attributed in part to the use of medetomidine hydrochloride (Domitor) for anesthesia. Consistent results in two different rat-brain systems, the sensorimotor and visual, strongly support the hypothesis that resting-state BOLD fluctuations are conserved across mammalian species and can be used to map brain systems.

引用

页码：1021 / 1029

页数：9

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