Development of intestinal M cells

被引：59

作者：

Mach, J ^{[1
]}

Hshieh, T ^{[1
]}

Hsieh, D ^{[1
]}

Grubbs, N ^{[1
]}

Chervonsky, A ^{[1
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

IMMUNOLOGICAL REVIEWS | 2005年 / 206卷

关键词：

D O I：

10.1111/j.0105-2896.2005.00281.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intestinal epithelium contains several specialized cell types including M cells, which can be found in the follicle-associated epithelium (FAE) or occasionally on the villi. M cells are critical for sampling of intestinal flora and for transferring pathogens across the epithelial barrier for recognition by the immune system. Development of M cells on the villi (M-v) is independent of the presence of lymphocytes, while development of the FAE and M cells within the FAE (M-f) is dependent on B lymphocytes. Here, the concept is discussed that B cells are not required for induction of M-f differentiation but are required for transition to and maintenance of the mature M-f phenotype. Signaling pathways possibly involved in the B-cell-independent stages of M-cell development are also discussed.

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收藏

页码：177 / 189

页数：13

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