Expression of hMTHI in the hippocampi of control and Alzheimer's disease

被引：42

作者：

Furuta, A

Iida, T

Nakabeppu, Y

Iwaki, T

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Neurol Inst, Dept Neuropathol,Higashi Ku, Fukuoka 8128582, Japan

[2] Kyushu Univ, Med Inst Bioregulat, Div Neurofunct Genom, Fukuoka 8128582, Japan

[3] Japan Sci & Technol Corp, CREST, Tsukuba, Ibaraki, Japan

来源：

NEUROREPORT | 2001年 / 12卷 / 13期

关键词：

Alzheimer's disease; hMTHI; mossy fiber synapse; oxidative stress; oxidized purine nucleoside triphosphatase;

D O I：

10.1097/00001756-200109170-00028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The oxidized purine nucleoside triphosphatase, hMTHI, has a critical role towards preventing errors caused by oxidized purine nucleoside triphosphates such as 8-oxo-dGTP and 2-hydroxy-dATP. We investigated the immunohistochemical expression of hMTHI in human hippocampal postmortem tissues representing non-neurological disease and Alzheimer's disease (AD). In the non-neurological subjects the hMTHI protein was enriched in the stratum lucidum at CA3 corresponding to mossy fiber synapses. In AD subjects, the synaptic immunoreactivities at CA3 were significantly decreased, whereas they tended to be increased at the entorhinal cortex. We suggest that the expression of hMTHI indicates indirect evidence of oxidative stress and its regulation is regionally differentiated in AD. NeuroReport 12:2895-2899 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：2895 / 2899

页数：5

共 21 条

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