Regulation of the C-Abl and Bcr-Abl tyrosine kinases

被引：395

作者：

Hantschel, O

Superti-Furga, G

机构：

[1] European Mol Biol Lab, Dev Biol Programme, D-69117 Heidelberg, Germany

[2] Cellzome AG, D-69117 Heidelberg, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 01期

关键词：

D O I：

10.1038/nrm1280

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The prototypic non-receptor tyrosine kinase c-Abl is implicated in various cellular processes. Its oncogenic counterpart, the Bcr-Abl fusion protein, causes certain human leukaemias. Recent insights into the structure and regulation of the c-Abl and Bcr-Abl tyrosine kinases have changed the way we look at these enzymes.

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页码：33 / 44

页数：12

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