Histone H1 diversity: bridging regulatory signals to linker histone function

被引：103

作者：

Khochbin, S ^{[1
]}

机构：

[1] Inst Albert Bonniot, Fac Med, INSERM U309,Lab Biol Mol & Cellulaire Differencia, Equipe Chromatine & Express Genes, F-38706 La Tronche, France

来源：

GENE | 2001年 / 271卷 / 01期

关键词：

transcription; acetylation; methylation; remodeling; differentiation;

D O I：

10.1016/S0378-1119(01)00495-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genes encoding linker histone variants have evolved to link their expression to signals controlling the proliferative capacities of cells, i.e. cycling and growth-arrested cells express distinct and specific HI subtypes. In metazoan, these variants show a tripartite structure, with considerably divergent sequences in their amino and carboxyl. terminus domains. The aim of this review is to show how specific regulatory signals control the expression of an individual H1 and to discuss the functional significance of the two variables associated with a linker histone: its primary sequence and the timing of its expression. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 12

页数：12

共 105 条

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