The Culture and Transplantation of Human Limbal Stem Cells

被引：48

作者：

Ahmad, Sajjad ^{[1
,2
,3
]}

Osei-Bempong, Charles ^{[2
]}

Dana, Reza ^{[4
,5
]}

Jurkunas, Ula ^{[4
,5
]}

机构：

[1] Newcastle Univ, Int Ctr Life, Inst Human Genet, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England

[2] Newcastle Univ, NE England Stem Cell Inst, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England

[3] Royal Victoria Infirm, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

[4] Harvard Univ, Schepens Eye Res Inst, Boston, MA 02115 USA

[5] Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2010年 / 225卷 / 01期

基金：

英国医学研究理事会;

关键词：

OCULAR SURFACE RECONSTRUCTION; SINGLE CORNEAL CELLS; EX-VIVO EXPANSION; EPITHELIAL-CELLS; IMPRESSION CYTOLOGY; DEFICIENCY; CONJUNCTIVA; DISORDERS; THERAPY; ORIGIN;

D O I：

10.1002/jcp.22251

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cornea is the clear front of the eye and its surface is composed of an epithelium. This is renewed by stem cells located at the limbus, which encircles the periphery of the cornea. These limbal stem cells become lost or deficient in the blinding disease of limbal stem cell deficiency. In this review article, we discuss the historical perspective in managing limbal stem cell deficiency as well as describing the more contemporary treatment options, and in particular the culture and transplantation of human limbal stem cells. This treatment was first proposed 13 years ago and many case series have been presented to date showing promising outcomes of this technique. However, challenges still remain in treating the debilitating disease of limbal stem cell deficiency. Here we discuss some of the questions, which remain to be answered in this field. J. Cell. Physiol. 225: 15-19,2010. (C) 2010 Wiley-Liss, Inc.

引用

页码：15 / 19

页数：5

共 40 条

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