Metformin Action: Concentrations Matter

被引：409

作者：

He, Ling ^{[1
,2
,3
]}

Wondisford, Fredric E. ^{[1
,2
,3
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Div Metab, Dept Pediat, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Div Metab, Dept Physiol, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Sch Med, Div Metab, Dept Med, Baltimore, MD 21287 USA

来源：

CELL METABOLISM | 2015年 / 21卷 / 02期

关键词：

ACTIVATED PROTEIN-KINASE; HEPATIC GLUCONEOGENESIS; PHOSPHORYLATION; AMP; HOMEOSTASIS; VARIANTS;

D O I：

10.1016/j.cmet.2015.01.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of metformin, 10-100 times higher than maximally achievable therapeutic concentrations found in patients with type 2 diabetes mellitus.

引用

页码：159 / 162

页数：4

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