Control of Gluconeogenesis by Metformin: Does Redox Trump Energy Charge?

被引：70

作者：

Baur, Joseph A. ^{[1
,2
]}

Birnbaum, Morris J. ^{[1
]}

机构：

[1] Univ Penn, Inst Diabet Obes & Metab, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Physiol, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

CELL METABOLISM | 2014年 / 20卷 / 02期

关键词：

DEHYDROGENASE; INHIBITION; MECHANISM; AMP;

D O I：

10.1016/j.cmet.2014.07.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Metformin is the most widely prescribed drug to lower glucose in type II diabetics, yet its mechanism of action remains controversial. A new study reveals that metformin inhibits mitochondrial glycerol-3-phosphate dehydrogenase, triggering reduction of the cytosolic NADH/NAD(+) pool and impaired utilization of redox-dependent substrates for gluconeogenesis (Madiraju et al., 2014).

引用

页码：197 / 199

页数：3

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