Reproducibility of 1H-NMR integrals:: a collaborative study

被引：25

作者：

Bauer, M

Bertario, A

Boccardi, G

Fontaine, X

Rao, R

Verrier, D

机构：

[1] Ctr Ric Midy Sanofi, I-20137 Milan, Italy

[2] Sanofi Rech, F-31036 Toulouse, France

[3] Sanofi Rech, F-34184 Montpellier, France

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1998年 / 17卷 / 03期

关键词：

quantitative NMR; reproducibility; interlaboratory study;

D O I：

10.1016/S0731-7085(97)00208-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The quantitative use of NMR spectroscopy was investigated by a reproducibility study of H-1-NMR integrals involving five laboratories. A significant laboratory effect was found confirming the difficulty to obtain very precise data by integration of complex signals. The reproducibility of any NMR assay measurement, which requires a high precision should be validated by an interlaboratory study. (C) 1998 Elsevier Science B.V.

引用

页码：419 / 425

页数：7

共 11 条

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DEROME AE, 1987, MODERN NMR TECHNIQUE, P168

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