Histopathology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

被引：299

作者：

Brown, Gregory Thomas ^{[1
]}

Kleiner, David E. ^{[1
]}

机构：

[1] NCI, Pathol Lab, Bldg 10,Room 25235,MSC 1500,10 Ctr Dr, Bethesda, MD 20892 USA

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2016年 / 65卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Steatohepatitis; Liver biopsy; Steatosis; Histology; BARIATRIC SURGERY; GASTRIC BYPASS; SCORING SYSTEM; PROGRESSION; STEATOSIS; FEATURES; WEIGHT; INJURY; NAFLD; MEGAMITOCHONDRIA;

D O I：

10.1016/j.metabol.2015.11.008

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Nonalcoholic fatty liver disease (NAFLD) is the liver injury most often associated with disorders of insulin resistance, including obesity, diabetes and the metabolic syndrome. The term encompasses several patterns of liver injury, including a relatively benign condition of steatosis without hepatocellular injury, nonalcoholic steatohepatitis (NASH), and a pattern of zone 1 steatosis, inflammation and fibrosis mainly observed in prepubertal children. Staging and grading systems have been developed to characterize the histological changes in NAFLD, mainly as a tool for clinical research. The histological features of NAFLD across these different manifestations and the scoring systems used to evaluate disease severity are discussed. Published by Elsevier Inc.

引用

页码：1080 / 1086

页数：7

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