In vitro comparison of the photothermal anticancer activity of graphene nanoparticles and carbon nanotubes

被引：482

作者：

Markovic, Zoran M. ^{[2
]}

Harhaji-Trajkovic, Ljubica M. ^{[3
]}

Todorovic-Markovic, Biljana M. ^{[2
]}

Kepic, Dejan P. ^{[2
]}

Arsikin, Katarina M. ^{[1
]}

Jovanovic, Svetlana P. ^{[2
]}

Pantovic, Aleksandar C. ^{[1
]}

Dramicanin, Miroslav D. ^{[2
]}

Trajkovic, Vladimir S. ^{[1
]}

机构：

[1] Univ Belgrade, Sch Med, Inst Microbiol & Immunol, Belgrade 11000, Serbia

[2] Univ Belgrade, Vinca Inst Nucl Sci, Belgrade 11000, Serbia

[3] Univ Belgrade, Inst Biol Res, Belgrade 11000, Serbia

来源：

BIOMATERIALS | 2011年 / 32卷 / 04期

关键词：

Graphene; Carbon nanotubes; Cancer; Hyperthermia; Apoptosis; APOPTOSIS; CANCER; NANOMATERIALS; NECROSIS; THERAPY; DEATH; CELLS;

D O I：

10.1016/j.biomaterials.2010.10.030

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

The present study compared the photothermal anticancer activity of near-infrared (NIR)-excited graphene nanoparticles and carbon nanotubes (CNT). Despite lower NIR-absorbing capacity, suspension of polyvinylpyrrolidone-coated graphene sheets exposed to NIR radiation (808 nm, 2 W/cm(2)) generated more heat than DNA or sodium dodecylbenzenesulfonate-solubilized single-wall CNT under the same conditions. Accordingly, graphene nanoparticles performed significantly better than CNT in inducing photothermal death of U251 human glioma cells in vitro. The superior photothermal sensitivity of graphene sheets could be largely explained by their better dispersivity, which has been supported by a simple calculation taking into account thermodynamic, optical and geometrical properties of the two type of carbon nanoparticles. The mechanisms of graphene-mediated photothermal killing of cancer cells apparently involved oxidative stress and mitochondrial membrane depolarization resulting in mixed apoptotic and necrotic cell death characterized by caspase activation/DNA fragmentation and cell membrane damage, respectively. (c) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1121 / 1129

页数：9

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