Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation

被引：272

作者：

Burke, Andrew ^{[2
]}

Ding, Xuanfeng ^{[3
]}

Singh, Ravi ^{[2
]}

Kraft, Robert A. ^{[3
]}

Levi-Polyachenko, Nicole ^{[4
]}

Rylander, Marissa Nichole ^{[8
,9
]}

Szot, Chris ^{[8
,9
]}

Buchanan, Cara ^{[8
,9
]}

Whitney, Jon ^{[8
,9
]}

Fisher, Jessica ^{[8
,9
]}

Hatcher, Heather C. ^{[2
]}

D'Agostino, Ralph, Jr. ^{[1
,5
]}

Kock, Nancy D. ^{[6
]}

Ajayan, P. M. ^{[10
]}

Carroll, David L. ^{[1
,11
]}

Akman, Steven ^{[1
,2
]}

Torti, Frank M. ^{[1
,2
]}

Torti, Suzy V. ^{[1
,7
]}

机构：

[1] Wake Forest Univ, Baptist Med Ctr, Ctr Comprehens Canc, Winston Salem, NC 27157 USA

[2] Wake Forest Univ, Sch Med, Dept Canc Biol, Winston Salem, NC 27157 USA

[3] Wake Forest Univ, Sch Med, Dept Phys & Radiat Oncol, Winston Salem, NC 27157 USA

[4] Wake Forest Univ, Sch Med, Dept Plast & Reconstruct Surg, Winston Salem, NC 27157 USA

[5] Wake Forest Univ, Sch Med, Dept Biostat Sci, Winston Salem, NC 27157 USA

[6] Wake Forest Univ, Sch Med, Dept Pathol, Winston Salem, NC 27157 USA

[7] Wake Forest Univ, Sch Med, Dept Biochem, Winston Salem, NC 27157 USA

[8] Virginia Polytech Inst & State Univ, Sch Biomed Engn, Blacksburg, VA 24061 USA

[9] Virginia Polytech Inst & State Univ, Dept Mech Engn, Blacksburg, VA 24061 USA

[10] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA

[11] Wake Forest Univ, Dept Phys, Winston Salem, NC 27109 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2009年 / 106卷 / 31期

基金：

美国国家卫生研究院;

关键词：

nanomedicine; thermal ablation; tumor therapy; photothermal therapy; heat shock proteins; THERMAL ABLATION; DESTRUCTION; DELIVERY; THERAPY; AGENTS; NANOPARTICLES; HYPERTHERMIA; MECHANISMS; RESISTANCE; CELLS;

D O I：

10.1073/pnas.0905195106

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Multiwalled carbon nanotubes (MWCNTs) exhibit physical properties that render them ideal candidates for application as noninvasive mediators of photothermal cancer ablation. Here, we demonstrate that use of MWCNTs to generate heat in response to near-infrared radiation (NIR) results in thermal destruction of kidney cancer in vitro and in vivo. We document the thermal effects of the therapy through magnetic resonance temperature-mapping and heat shock protein-reactive immunohistochemistry. Our results demonstrate that use of MWCNTs enables ablation of tumors with low laser powers (3 W/cm(2)) and very short treatment times (a single 30-sec treatment) with minimal local toxicity and no evident systemic toxicity. These treatment parameters resulted in complete ablation of tumors and a >3.5-month durable remission in 80% of mice treated with 100 mu g of MWCNT. Use of MWCNTs with NIR may be effective in anticancer therapy.

引用

页码：12897 / 12902

页数：6

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