IS26-Associated In4-type integrons forming multiresistance loci in enterobacterial plasmids

被引：69

作者：

Miriagou, V

Carattoli, A

Tzelepi, E

Villa, L

Tzouvelekis, LS

机构：

[1] Hellenic Pasteur Inst, Bacteriol Lab, Athens 11521, Greece

[2] Univ Athens, Sch Med, Dept Microbiol, GR-11527 Athens, Greece

[3] Ist Super Sanita, Dept Infect Dis, I-00161 Rome, Italy

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 08期

关键词：

D O I：

10.1128/AAC.49.8.3541-3543.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Three distinct multiresistant loci from enterobacterial plasmids each comprised an integron and an IS26-associated sequence. Sequence comparison suggested a common ancestral structure that derived from an IS26 insertion into the 5' conserved segment of an In4-type integron and evolved through acquisition of gene cassettes and IS26-mediated recruitment of additional resistance genes of diverse origin.

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页码：3541 / 3543

页数：3

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