Selective Alkylation of (Hetero)Aromatic Amines with Alcohols Catalyzed by a Ruthenium Pincer Complex

被引：124

作者：

Agrawal, Santosh ^{[1
]}

Lenormand, Maud ^{[1
]}

Martin-Matute, Belen ^{[1
]}

机构：

[1] Stockholm Univ, Dept Organ Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 06期

基金：

瑞典研究理事会;

关键词：

N-ALKYLATION; BORROWING HYDROGEN; REDUCTIVE ALKYLATION; EFFICIENT CATALYSTS; AROMATIC-AMINES; AMINATION; HYDROAMINATION; SULFONAMIDES; DIAMINES; VERSATILE;

D O I：

10.1021/ol3001969

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A readily available pincer ruthenium(II) complex catalyzes the selective monoalkylation of (hetero)aromatic amines with a wide range of primary alcohols (including pyridine-, furan-, and thiophene-substituted alcohols) with high efficiency when used in low catalyst loadings (1 mol %). Tertiary amine formation via polyalkylation does not occur, making this ruthenium system an excellent catalyst for the synthesis of sec-amines.

引用

页码：1456 / 1459

页数：4

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