Catalytic Alkylation of Methyl-N-Heteroaromatics with Alcohols

被引：132

作者：

Blank, Benoit ^{[1
]}

Kempe, Rhett ^{[1
]}

机构：

[1] Univ Bayreuth, D-95440 Bayreuth, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 03期

关键词：

ASTERISK-IR COMPLEX; BORROWING HYDROGEN; SECONDARY ALCOHOLS; BETA-ALKYLATION; HETEROCYCLIC CARBENE; TERTIARY-AMINES; ACTIVATION; AMINATION; COORDINATION; VERSATILE;

D O I：

10.1021/ja9095413

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel Catalytic C-C coupling reaction in which N-heteroaromatic-substituted methyl groups are efficiently alkylated using, primary alcohols is introduced. The synthesis protocol is based on iridium catalysts and most likely relies on the "borrowing hydrogen" or "hydrogen autotransfer" mechanism. A variety Of substrate combinations can readily be employed in this reaction, including pyrimidines, pyridazines, and even fairly activated 2- and 4-picolines.

引用

收藏

页码：924 / +

页数：3

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