N-alkylation of phenethylamine and tryptamine

被引：94

作者：

Cami-Kobeci, G ^{[1
]}

Slatford, PA ^{[1
]}

Whittlesey, MK ^{[1
]}

Williams, JMJ ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 03期

基金：

英国工程与自然科学研究理事会;

关键词：

iridium; tryptamine; oxidation; reduction;

D O I：

10.1016/j.bmcl.2004.11.050

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A clean and efficient method for the N-alkylation of tryptamine and phenethylamine, employing alcohols as the alkylating agents, has been developed. The reaction proceeds via catalytic electronic activation, involving an iridium catalyst which activates the alcohol by borrowing hydrogen from the substrate, returning it later in the catalytic cycle. Some examples of N-heterocyclisation have been performed employing a diol as the substrate. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：535 / 537

页数：3

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