Synthesis of a potent inhibitor of beta-glucuronidase

被引：34

作者：

Igarashi, Y ^{[1
]}

Ichikawa, M ^{[1
]}

Ichikawa, Y ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & MOLEC SCI,BALTIMORE,MD 21205

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 16期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(96)00422-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new glucuronic acid-type iminosugar in which a nitrogen atom is placed in the anomeric positon was synthesized and was proven to potently inhibit beta-glucuronidase, with Ki = 79 nM. Copyright (C) 1996 Elsevier Science Ltd.

引用

页码：2707 / 2708

页数：2

共 10 条

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