DNA is bound within the central hole to one or two of the six subunits of the T7 DNA helicase

被引:113
作者
Yu, X
Hingorani, MM
Patel, SS
Egelman, EH
机构
[1] UNIV MINNESOTA, SCH MED, DEPT CELL BIOL & NEUROANAT, MINNEAPOLIS, MN 55455 USA
[2] OHIO STATE UNIV, DEPT BIOCHEM, COLUMBUS, OH 43210 USA
来源
NATURE STRUCTURAL BIOLOGY | 1996年 / 3卷 / 09期
关键词
D O I
10.1038/nsb0996-740
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Electron microscopic image analysis and protein-DNA crosslinking show that DNA binds asymmetrically to the hexameric bacteriophage T7 gp4b helicase, and binds to only one or two subunits.
引用
收藏
页码:740 / 743
页数:4
相关论文
共 23 条
[1]   INTERACTIONS OF ESCHERICHIA-COLI PRIMARY REPLICATIVE HELICASE DNAB PROTEIN WITH SINGLE-STRANDED-DNA - THE NUCLEIC-ACID DOES NOT WRAP AROUND THE PROTEIN HEXAMER [J].
BUJALOWSKI, W ;
JEZEWSKA, MJ .
BIOCHEMISTRY, 1995, 34 (27) :8513-8519
[2]   HARMONIC ANALYSIS OF ELECTRON MICROSCOPE IMAGES WITH ROTATIONAL SYMMETRY [J].
CROWTHER, RA ;
AMOS, LA .
JOURNAL OF MOLECULAR BIOLOGY, 1971, 60 (01) :123-&
[3]  
DEAN FB, 1992, J BIOL CHEM, V267, P14129
[4]   COMPLETE NUCLEOTIDE-SEQUENCE OF BACTERIOPHAGE-T7 DNA AND THE LOCATIONS OF T7 GENETIC ELEMENTS [J].
DUNN, JJ ;
STUDIER, FW .
JOURNAL OF MOLECULAR BIOLOGY, 1983, 166 (04) :477-535
[5]   BACTERIOPHAGE-T7 HELICASE-PRIMASE PROTEINS FORM RINGS AROUND SINGLE-STRANDED-DNA THAT SUGGEST A GENERAL STRUCTURE FOR HEXAMERIC HELICASES [J].
EGELMAN, EH ;
YU, X ;
WILD, R ;
HINGORANI, MM ;
PATEL, SS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (09) :3869-3873
[6]   THE LOCATION OF DNA IN RECA-DNA HELICAL FILAMENTS [J].
EGELMAN, EH ;
YU, X .
SCIENCE, 1989, 245 (4916) :404-407
[7]   2 RELATED SUPERFAMILIES OF PUTATIVE HELICASES INVOLVED IN REPLICATION, RECOMBINATION, REPAIR AND EXPRESSION OF DNA AND RNA GENOMES [J].
GORBALENYA, AE ;
KOONIN, EV ;
DONCHENKO, AP ;
BLINOV, VM .
NUCLEIC ACIDS RESEARCH, 1989, 17 (12) :4713-4730
[8]   HELICASES - AMINO-ACID-SEQUENCE COMPARISONS AND STRUCTURE-FUNCTION-RELATIONSHIPS [J].
GORBALENYA, AE ;
KOONIN, EV .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 1993, 3 (03) :419-429
[9]   INTERACTIONS OF BACTERIOPHAGE-T7 DNA PRIMASE HELICASE PROTEIN WITH SINGLE-STRANDED AND DOUBLE-STRANDED DNAS [J].
HINGORANI, MM ;
PATEL, SS .
BIOCHEMISTRY, 1993, 32 (46) :12478-12487
[10]   Cooperative interactions of nucleotide ligands are linked to oligomerization and DNA binding in bacteriophage T7 gene 4 helicases [J].
Hingorani, MM ;
Patel, SS .
BIOCHEMISTRY, 1996, 35 (07) :2218-2228