C. elegans cell cycles:: Invariance and stem cell divisions

被引:51
作者
Kipreos, ET [1 ]
机构
[1] Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/nrm1738
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The adult Caenorhabditis elegans nematode, a small roundworm, has a precisely defined number of somatic cells that create organs that are also found in larger animals, including intestine, muscles, skin, an excretory system and a primitive brain. Every cell has a defined role in this sophisticated, but tiny animal. Therefore, stringent control of the cell cycle is required to produce the almost invariant cell lineage that generates the C. elegans somatic body plan. The proliferation of germ cells is regulated differently, and occurs within a stem cell niche.
引用
收藏
页码:766 / 776
页数:11
相关论文
共 91 条
[1]   CELL CYCLING AND DNA-REPLICATION IN A MUTANT BLOCKED IN CELL-DIVISION IN NEMATODE CAENORHABDITIS-ELEGANS [J].
ALBERTSON, DG ;
SULSTON, JE ;
WHITE, JG .
DEVELOPMENTAL BIOLOGY, 1978, 63 (01) :165-178
[2]  
Ambros V, 1999, DEVELOPMENT, V126, P1947
[3]   HETEROCHRONIC MUTANTS OF THE NEMATODE CAENORHABDITIS-ELEGANS [J].
AMBROS, V ;
HORVITZ, HR .
SCIENCE, 1984, 226 (4673) :409-416
[4]   The temporal control of cell cycle and cell fate in Caenorhabditis elegans [J].
Ambros, V .
CELL CYCLE AND DEVELOPMENT, 2001, 237 :203-220
[5]   The natural history of Caenorhabditis elegans research [J].
Ankeny, RA .
NATURE REVIEWS GENETICS, 2001, 2 (06) :474-479
[6]   CDC-25.1 regulates germline proliferation in Caenorhabditis elegans [J].
Ashcroft, N ;
Golden, A .
GENESIS, 2002, 33 (01) :1-7
[7]   GLP-1 IS REQUIRED IN THE GERM LINE FOR REGULATION OF THE DECISION BETWEEN MITOSIS AND MEIOSIS IN C-ELEGANS [J].
AUSTIN, J ;
KIMBLE, J .
CELL, 1987, 51 (04) :589-599
[8]  
Berry LW, 1997, DEVELOPMENT, V124, P925
[9]   The Restriction Point of the Cell Cycle [J].
Blagosklonny, Mikhail V. ;
Pardee, Arthur B. .
CELL CYCLE, 2002, 1 (02) :103-110
[10]   Replication licensing - defining the proliferative state? [J].
Blow, JJ ;
Hodgson, B .
TRENDS IN CELL BIOLOGY, 2002, 12 (02) :72-78