Enantioselective Aldol Reaction using Recyclable Montmorillonite-Entrapped N-(2-Thiophenesulfonyl)prolinamide

被引：69

作者：

Hara, Noriyuki ^{[1
]}

Nakamura, Shuichi ^{[1
]}

Shibata, Norio ^{[1
]}

Toru, Takeshi ^{[1
]}

机构：

[1] Nagoya Inst Technol, Grad Sch Engn, Dept Frontier Mat, Showa Ku, Nagoya, Aichi 4668555, Japan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 10期

关键词：

aldol reaction; enantioselectivity; heteroarenesulfonyl group; Montmorillonite; organocatalysis; DERIVATIVES; (R)-CONVOLUTAMYDINE; ACETALDEHYDE; ALKALOIDS;

D O I：

10.1002/adsc.201000214

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

N-(2-Thiophenesulfonyl)prolinamide could be easily introduced into Montmorillonite by a simple ion-exchange reaction. The asymmetric aldol reactions between various isatins with acetone or acetaldehyde using a heterogeneous Montmorillonite-entrapped organocatalyst afforded products with high enantioselectivity. The catalyst was readily reusable without significant loss of catalytic activity or enantioselectivity.

引用

页码：1621 / 1624

页数：4

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