Postantibiotic effect of antimicrobial combinations on multidrug-resistant Pseudomonas aeruginosa

被引：21

作者：

Giamarellos-Bourboulis, EJ ^{[1
]}

Kentepozidis, N ^{[1
]}

Antonopoulou, A ^{[1
]}

Plachouras, D ^{[1
]}

Tsaganos, T ^{[1
]}

Giamarellou, H ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Dept Internal Med 4, Athens 12464, Greece

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2005年 / 51卷 / 02期

关键词：

ceftazidime; imipenem; ciprofloxacin; amikacin; postantibiotic effect; resistance;

D O I：

10.1016/j.diagmicrobio.2004.09.004

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The application of antimicrobial combinations on multidrug-resistant Pseudomonas aeruginosa might be of clinical relevance if they possess a significant postantibiotic effect (PAE). Twenty-two nosocomial isolates were exposed over time to ceftazidime, imipenem, or ciprofloxacin, and to their interaction with amikacin; all were applied at concentrations equal to their average serum level. After 24 h of exposure, live cells were washed and resuspended into fresh broth, and bacterial growth was monitored. PAE was found only for isolates subjected to the synergistic effect of the applied interactions. For these isolates, the mean PAEs (+/- SE) were 3.10 +/- 0.71 h for ceftazidime and amikacin, 4.38 +/- 0.83 h for imipenem and amikacin, and 3.33 +/- 2.83 h for ciprofloxacin and amikacin. The prolonged PAE documented after exposure to the interactions of the studied drugs strengthens the application of their combination for the management of infections by multidrug-resistant P. aeruginosa. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：113 / 117

页数：5

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