Synthesis and characterization of collagen/hydroxyapatite: magnetite composite material for bone cancer treatment

被引：125

作者：

Andronescu, Ecaterina ^{[1
]}

Ficai, Maria ^{[1
]}

Voicu, Georgeta ^{[1
]}

Ficai, Denisa ^{[1
]}

Maganu, Maria ^{[2
]}

Ficai, Anton ^{[1
]}

机构：

[1] Univ Politehn Bucuresti, Fac Appl Chem & Mat Sci, Bucharest 011061, Romania

[2] Acad Romana, Ctr Organ Chem Costin D Nenitescu, Bucharest 050461, Romania

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2010年 / 21卷 / 07期

关键词：

TUMOR-BEARING MICE; DRUG-DELIVERY; NANOPARTICLES; CISPLATIN; CHITOSAN; RELEASE; HYDROGEL; THERAPY; ACID;

D O I：

10.1007/s10856-010-4076-7

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Our purpose was obtaining and characterizing a complex composite system with multifunctional role: bone graft material and hyperthermia generator necessary for bone cancer therapy. The designed system was a magnetite enriched collagen/hydroxyapatite composite material, obtained by a co-precipitation method. Due to the applied electromagnetic field the magnetite will induce hyperthermia and cause tumoral cell apoptosis. The complex bone graft system was characterised by XRD, FTIR and SEM, while the hyperthermia was quantify by measuring the temperature increase due to the applied alternative electromagnetical field.

引用

页码：2237 / 2242

页数：6

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