Surface Modification-Complexation Strategy for Cisplatin Loading in Mesoporous Nanoparticles

被引：73

作者：

Gu, Jinlou ^{[1
]}

Su, Shasha ^{[1
]}

Li, Yongsheng ^{[1
]}

He, Qianjun ^{[2
]}

Zhong, Flaying ^{[1
]}

Shi, Jianlin ^{[1
,2
]}

机构：

[1] E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

来源：

JOURNAL OF PHYSICAL CHEMISTRY LETTERS | 2010年 / 1卷 / 24期

关键词：

HYBRID SILICA NANOPARTICLES; DRUG-DELIVERY; CONTROLLED-RELEASE; CANCER-CELLS; GOLD NANOPARTICLES; TARGETED DELIVERY; FUNCTIONALIZATION; POLYMERS; SYSTEMS;

D O I：

10.1021/jz101483u

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

High-density carboxyl groups have been successfully grafted onto the pore surface of mesoporous nanocarriers which served to complex with platinum atoms in cisplatin, leading to much increased drug loading efficiency, distinctly prolonged and pH-responsive cisplatin release, and greatly enhanced growth inhibition effect against MCF-7 and HeLa cancer cell lines.

引用

收藏

页码：3446 / 3450

页数：5

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