GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI

被引：290

作者：

Northoff, Georg

Walter, Martin

Schulte, Rolf F.

Beck, Johannes

Dydak, Ulrike

Henning, Anke

Boeker, Heinz

Grimm, Simone

Boesiger, Peter

机构：

[1] Univ Magdeburg, Dept Psychiat, D-39120 Magdeburg, Germany

[2] Univ Zurich, ETH Zurich, Inst Biomed Engn, CH-8092 Zurich, Switzerland

[3] Univ Zurich, Dept Psychiat, CH-8029 Zurich, Switzerland

来源：

NATURE NEUROSCIENCE | 2007年 / 10卷 / 12期

关键词：

D O I：

10.1038/nn2001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The human anterior cingulate cortex (ACC) is part of the default-mode network that shows predominant negative blood oxygen level-dependent (BOLD) responses in functional magnetic resonance imaging (fMRI). We combined fMRI during emotional processing and resting-state magnetic resonance spectroscopy measurements and observed that the concentration of GABA in the ACC specifically correlated with the amount of negative BOLD responses in the very same region. Our findings show that default-mode network negative BOLD responses during emotions are mediated by GABA.

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页码：1515 / 1517

页数：3

相关论文

共 15 条

[1] Conceptual processing during the conscious resting state: A functional MRI study [J].

Binder, JR ;

Frost, JA ;

Hammeke, TA ;

Bellgowan, PSF ;

Rao, SM ;

Cox, RW .

JOURNAL OF COGNITIVE NEUROSCIENCE, 1999, 11 (01) :80-93

[2] Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues [J].

Crestani, F ;

Lorez, M ;

Baer, K ;

Essrich, C ;

Benke, D ;

Laurent, JP ;

Belzung, C ;

Fritschy, JM ;

Lüscher, B ;

Mohler, H .

NATURE NEUROSCIENCE, 1999, 2 (09) :833-839

[3] Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signal [J].

Devor, Anna ;

Tian, Peifang ;

Nishimura, Nozomi ;

Teng, Ivan C. ;

Hillman, Elizabeth M. C. ;

Narayanan, S. N. ;

Ulbert, Istvan ;

Boas, David A. ;

Kleinfeld, David ;

Dale, Anders M. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (16) :4452-4459

[4] Spontaneous low-frequency BOLD signal fluctuations: An fMRI investigation of the resting-state default mode of brain function hypothesis [J].

Fransson, P .

HUMAN BRAIN MAPPING, 2005, 26 (01) :15-29

[5] Searching for a baseline: Functional imaging and the resting human brain [J].

Gusnard, DA ;

Raichle, ME .

NATURE REVIEWS NEUROSCIENCE, 2001, 2 (10) :685-694

[6] Molecular and neuronal substrate for the selective attenuation of anxiety [J].

Löw, K ;

Crestani, F ;

Keist, R ;

Benke, D ;

Brünig, I ;

Benson, JA ;

Fritschy, JM ;

Rülicke, T ;

Bluethmann, H ;

Möhler, H ;

Rudolph, U .

SCIENCE, 2000, 290 (5489) :131-134

[7] A parametric manipulation of factors affecting task-induced deactivation in functional neuroimaging [J].

McKiernan, KA ;

Kaufman, JN ;

Kucera-Thompson, J ;

Binder, JR .

JOURNAL OF COGNITIVE NEUROSCIENCE, 2003, 15 (03) :394-408

[8] Reciprocal modulation and attenuation in the prefrontal cortex: An fMRI study on emotional-cognitive interaction [J].

Northoff, G ;

Heinzel, A ;

Bermpohl, F ;

Niese, R ;

Pfennig, A ;

Pascual-Leone, A ;

Schlaug, G .

HUMAN BRAIN MAPPING, 2004, 21 (03) :202-212

[9] GABA-ergic modulation of prefrontal spatio-temporal activation pattern during emotional processing:: A combined fMRI/MEG study with placebo and lorazepam [J].

Northoff, G ;

Witzel, T ;

Richter, A ;

Gessner, M ;

Schlagenhauf, F ;

Fell, J ;

Baumgart, F ;

Kaulisch, T ;

Tempelmann, C ;

Heinzel, A ;

Kötter, R ;

Hagner, T ;

Bargel, B ;

Hinrichs, H ;

Bogerts, B ;

Scheich, H ;

Heinze, HJ .

JOURNAL OF COGNITIVE NEUROSCIENCE, 2002, 14 (03) :348-370

[10] Analysis of oxygen metabolism implies a neural origin for the negative BOLD response in human visual cortex [J].

Pasley, Brian N. ;

Inglis, Ben A. ;

Freeman, Ralph D. .

NEUROIMAGE, 2007, 36 (02) :269-276