Finding NEMO:: genetic disorders of NF-κB activation

被引：40

作者：

Orange, JS

Geha, RS

机构：

[1] Childrens Hosp, Div Immunol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 07期

关键词：

D O I：

10.1172/JCI200319960

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The pathways between a receptor and transcriptional activation mediated by NF-kappaB are complex. The study of human gene mutations that result in dysregulation of these pathways has provided insight into the functions of individual components of the pathway, their interrelations, and the significance of these systems to the organism (see the related article beginning on page 1108).

引用

页码：983 / 985

页数：3

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