In Vivo Bioluminescent Imaging (BLI): Noninvasive Visualization and Interrogation of Biological Processes in Living Animals

被引：142

作者：

Close, Dan M. ^{[1
]}

Xu, Tingting ^{[1
]}

Sayler, Gary S. ^{[1
]}

Ripp, Steven ^{[1
]}

机构：

[1] Univ Tennessee, Ctr Environm Biotechnol, Knoxville, TN 37996 USA

来源：

SENSORS | 2011年 / 11卷 / 01期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

bacterial luciferase; bioluminescent imaging; BLI; firefly luciferase; Lux; Luc; MESENCHYMAL STEM-CELLS; PROTEIN-PROTEIN INTERACTIONS; INDUCIBLE FACTOR 1-ALPHA; FIREFLY LUCIFERASE; GENE-EXPRESSION; STREPTOCOCCUS-PNEUMONIAE; TOXOPLASMA-GONDII; WOUND INFECTIONS; ENERGY-TRANSFER; REPORTER MOUSE;

D O I：

10.3390/s110100180

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In vivo bioluminescent imaging (BLI) is increasingly being utilized as a method for modern biological research. This process, which involves the noninvasive interrogation of living animals using light emitted from luciferase-expressing bioreporter cells, has been applied to study a wide range of biomolecular functions such as gene function, drug discovery and development, cellular trafficking, protein-protein interactions, and especially tumorigenesis, cancer treatment, and disease progression. This article will review the various bioreporter/biosensor integrations of BLI and discuss how BLI is being applied towards a new visual understanding of biological processes within the living organism.

引用

页码：180 / 206

页数：27

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