Noncoding RNAs as potential biomarkers to predict the outcome in pancreatic cancer

被引：21

作者：

Jin, Kaizhou ^{[1
,2
,3
]}

Luo, Guopei ^{[1
,2
,3
]}

Xiao, Zhiwen ^{[1
,2
,3
]}

Liu, Zuqiang ^{[1
,2
,3
]}

Liu, Chen ^{[1
,2
,3
]}

Ji, Shunrong ^{[1
,2
,3
]}

Xu, Jin ^{[1
,2
,3
]}

Liu, Liang ^{[1
,2
,3
]}

Long, Jiang ^{[1
,2
,3
]}

Ni, Quanxing ^{[1
,2
,3
]}

Yu, Xianjun ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Dept Pancreat & Hepatobiliary Surg, Shanghai Canc Ctr, Shanghai 200032, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China

[3] Fudan Univ, Pancreat Canc Inst, Shanghai 200032, Peoples R China

来源：

DRUG DESIGN DEVELOPMENT AND THERAPY | 2015年 / 9卷

基金：

美国国家科学基金会;

关键词：

pancreatic ductal adenocarcinoma; microRNA; long noncoding RNA; outcome prediction; EPITHELIAL-MESENCHYMAL TRANSITION; INDEPENDENT PROGNOSTIC-FACTOR; INHIBITS CELL-PROLIFERATION; HEPATOCELLULAR-CARCINOMA; CIRCULATING MICRORNAS; EXPRESSION PROFILE; TUMOR-SUPPRESSOR; DOWN-REGULATION; BREAST-CANCER; C-MYC;

D O I：

10.2147/DDDT.S77597

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Pancreatic ductal adenocarcinoma (PDAC), a common digestive system cancer, is highly malignant and has a poor disease outcome. Currently, all available examination and detection methods cannot accurately predict the clinical outcome. Therefore, it is extremely important to identify novel molecular biomarkers for personalized medication and to significantly improve the overall outcome. The "noncoding RNAs" (ncRNAs) are a group of RNAs that do not code for proteins, and they are categorized as structural RNAs and regulatory RNAs. It has been shown that microRNAs and long ncRNAs function as regulatory RNAs to affect the progression of various diseases. Many studies have confirmed a role for ncRNAs in the progression of PDAC during the last few years. Because of the significant role of ncRNAs in PDAC, ncRNA profiling may be used to predict PDAC outcome with high accuracy. This review comprehensively analyzes the value of ncRNAs as potential biomarkers to predict the outcome in PDAC and the possible mechanisms thereof.

引用

页码：1247 / 1255

页数：9

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