Development of a multiarray biosensor for DNA diagnostics

被引：14

作者：

Vo-Dinh, T ^{[1
]}

Isola, N ^{[1
]}

Alarie, JP ^{[1
]}

Landis, D ^{[1
]}

Griffin, GD ^{[1
]}

Allison, S ^{[1
]}

机构：

[1] Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA

来源：

INSTRUMENTATION SCIENCE & TECHNOLOGY | 1998年 / 26卷 / 05期

关键词：

D O I：

10.1080/10739149808000917

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This work involves the development and evaluation of a multiarray biosensor for DNA diagnostics. The evaluation of various system components developed for the biosensor is discussed. The DNA probes labeled with visible and near infrared (NIR) dyes are evaluated. The detection system uses a two-dimensional charge-coupled device (CCD). Examples of application of gene probes in DNA hybridization experiments and in biomedical diagnosis (detection of the p53 cancer gene) are presented to illustrate the usefulness and potential of the biosensor device.

引用

页码：503 / 514

页数：12

共 14 条

[1] INTENSIFIED CHARGE COUPLED DEVICE-BASED FIBEROPTIC MONITOR FOR RAPID REMOTE SURFACE-ENHANCED RAMAN-SCATTERING SENSING [J].