Research and development in biosensors

被引:199
作者
Scheller, FW
Wollenberger, U
Warsinke, A
Lisdat, F
机构
[1] Univ Potsdam, Inst Biochem & Biol, D-14476 Golm, Germany
[2] Univ Tokyo, Ctr Collaborat Res, Meguro Ku, Tokyo, Japan
关键词
D O I
10.1016/S0958-1669(00)00169-5
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Progress in biosensors has mainly been made by the improvement of the biological components and the implementation of microsystem technologies. Enzymes are still the most appropriate recognition elements because they combine high chemical specificity and inherent biocatalytic signal amplification. A breakthrough has been achieved in the application of membrane-integrated receptor systems for analyte recognition and signal transduction in biosensors. Sensor integration of RNA aptamers has been initiated, and the performance of fully synthetic molecularly imprinted polymers has been improved.
引用
收藏
页码:35 / 40
页数:6
相关论文
共 55 条
[1]   Recent developments in faradaic bioelectrochemistry [J].
Armstrong, FA ;
Wilson, GS .
ELECTROCHIMICA ACTA, 2000, 45 (15-16) :2623-2645
[2]   Cellular applications of a sensitive and selective fiber optic nitric oxide biosensor based on a dye-labeled heme domain of soluble guanylate cyclase [J].
Barker, SLR ;
Zhao, YD ;
Marletta, MA ;
Kopelman, R .
ANALYTICAL CHEMISTRY, 1999, 71 (11) :2071-2075
[3]   Ratiometric and fluorescence lifetime-based biosensors incorporating cytochrome c′ and the detection of extra- and intracellular macrophage nitric oxide [J].
Barker, SLR ;
Clark, HA ;
Swallen, SF ;
Kopelman, R ;
Tsang, AW ;
Swanson, JA .
ANALYTICAL CHEMISTRY, 1999, 71 (09) :1767-1772
[4]   Development of a creatinine ELISA and an amperometric antibody-based creatinine sensor with a detection limit in the nanomolar range [J].
Benkert, A ;
Scheller, F ;
Schössler, W ;
Hentschel, C ;
Micheel, B ;
Behrsing, O ;
Scharte, G ;
Stöcklein, W ;
Warsinke, A .
ANALYTICAL CHEMISTRY, 2000, 72 (05) :916-921
[5]  
BENKERT A, 2000, IN PRESS ELECTROANAL
[6]  
Berggren C, 1999, ELECTROANAL, V11, P156, DOI 10.1002/(SICI)1521-4109(199903)11:3<156::AID-ELAN156>3.0.CO
[7]  
2-O
[8]   Small antibody-like proteins with prescribed ligand specificities derived from the lipocalin fold [J].
Beste, G ;
Schmidt, FS ;
Stibora, T ;
Skerra, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (05) :1898-1903
[9]   INTEGRATED OPTICAL IMMUNOSENSOR FOR S-TRIAZINE DETERMINATION - REGENERATION, CALIBRATION AND LIMITATIONS [J].
BIER, FF ;
JOCKERS, R ;
SCHMID, RD .
ANALYST, 1994, 119 (03) :437-441
[10]   Micropatterned immobilization of a G protein-coupled receptor and direct detection of G protein activation [J].
Bieri, C ;
Ernst, OP ;
Heyse, S ;
Hofmann, KP ;
Vogel, H .
NATURE BIOTECHNOLOGY, 1999, 17 (11) :1105-1108