Epigenetics in Alternative Pre-mRNA Splicing

被引：620

作者：

Luco, Reini F. ^{[1
]}

Allo, Mariano ^{[2
,3
]}

Schor, Ignacio E. ^{[2
,3
]}

Kornblihtt, Alberto R. ^{[2
,3
]}

Misteli, Tom ^{[1
]}

机构：

[1] NCI, NIH, Bethesda, MD 20892 USA

[2] Univ Buenos Aires, Fac Ciencias Exactas Nat, LFBM, Dept Fisiol Biol Mol, Buenos Aires, DF, Argentina

[3] Univ Buenos Aires, Fac Ciencias Exactas Nat, IFIBYNE CONICET, Buenos Aires, DF, Argentina

来源：

CELL | 2011年 / 144卷 / 01期

基金：

美国国家卫生研究院;

关键词：

CARBOXY-TERMINAL DOMAIN; SR PROTEIN FAMILY; POLYMERASE-II; DNA METHYLATION; INTRON REMOVAL; TRANSCRIPTION; RECRUITMENT; BINDING; POLYADENYLATION; YEAST;

D O I：

10.1016/j.cell.2010.11.056

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alternative splicing plays critical roles in differentiation, development, and disease and is a major source for protein diversity in higher eukaryotes. Analysis of alternative splicing regulation has traditionally focused on RNA sequence elements and their associated splicing factors, but recent provocative studies point to a key function of chromatin structure and histone modifications in alternative splicing regulation. These insights suggest that epigenetic regulation determines not only what parts of the genome are expressed but also how they are spliced.

引用

页码：16 / 26

页数：11

共 94 条

[91] A genome-wide RNA interference screen reveals that variant histones, are necessary for replication-dependent histone pre-mRNA processing [J].