The non-mevalonate pathway of isoprenoid precursor biosynthesis

被引：245

作者：

Hunter, William N. ^{[1
]}

机构：

[1] Univ Dundee, Coll Life Sci, Div Biol Chem & Drug Discovery, Dundee DD1 5EH, Scotland

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2007年 / 282卷 / 30期

基金：

英国惠康基金;

关键词：

D O I：

10.1074/jbc.R700005200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The recently discovered non-mevalonate biosynthetic route to isoprenoid precursors is an essential metabolic pathway in plants, apicomplexan parasites, and many species of bacteria. The pathway relies on eight enzymes exploiting different cofactors and metal ions. Structural and mechanistic data now exist for most components of the pathway though there remain some gaps in our knowledge. The individual enzymes represent new, validated targets for broad spectrum antimicrobial drug and herbicide development. Detailed knowledge of the pathway may also be exploited to genetically modify microorganisms and plants to produce compounds of agricultural and medical interest.

引用

页码：21573 / 21577

页数：5

共 52 条

[1] A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae [J].

Akerley, BJ ;

Rubin, EJ ;

Novick, VL ;

Amaya, K ;

Judson, N ;

Mekalanos, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (02) :966-971

[2]

BORK P, 1993, PROTEIN SCI, V2, P31

[3] The methylerythritol phosphate pathway is functionally active in all intraerythrocytic stages of Plasmodium falciparum [J].

Cassera, MB ;

Gozzo, FC ;

D'Alexandri, FL ;

Merino, EF ;

del Portillo, HA ;

Peres, VJ ;

Almeida, IC ;

Eberlin, MN ;

Wunderlich, G ;

Wiesner, J ;

Jomaa, H ;

Kimura, EA ;

Katzin, AM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (50) :51749-51759

[4] Structure of Thermus thermophilus type 2 isopentenyl diphosphate isomerase inferred from crystallography and molecular dynamics [J].

de Ruyck, J ;

Rothman, SC ;

Poulter, CD ;

Wouters, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 338 (03) :1515-1518

[5] Crystal structure of isopentenyl diphosphate:dimethylallyl diphosphate isomerase [J].

Durbecq, V ;

Sainz, G ;

Oudjama, Y ;

Clantin, B ;

Bompard-Gilles, C ;

Tricot, C ;

Caillet, J ;

Stalon, V ;

Droogmans, L ;

Villeret, V .

EMBO JOURNAL, 2001, 20 (07) :1530-1537

[6] Deoxyxylulose phosphate pathway to terpenoids [J].

Eisenreich, W ;

Rohdich, F ;

Bacher, A .

TRENDS IN PLANT SCIENCE, 2001, 6 (02) :78-84

[7] Biosynthesis of isoprenoids via the non-mevalonate pathway [J].

Eisenreich, W ;

Bacher, A ;

Arigoni, D ;

Rohdich, F .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2004, 61 (12) :1401-1426

[8] Snapshot of a key intermediate in enzymatic thiamin catalysis:: Crystal structure of the α-carbanion of (α,β-dihydroxyethyl)-thiamin diphosphate in the active site of transketolase from Saccharomyces cerevisiae [J].

Fiedler, E ;

Thorell, S ;

Sandalova, T ;

Golbik, R ;

König, S ;

Schneider, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (02) :591-595

[9] The crystal structure of a plant 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate [J].

Gabrielsen, M ;

Kaiser, J ;

Rohdich, F ;

Eisenreich, W ;

Laupitz, R ;

Bacher, A ;

Bond, CS ;

Hunter, WN .

FEBS JOURNAL, 2006, 273 (05) :1065-1073

[10] Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis [J].

Gabrielsen, M ;

Bond, CS ;

Hallyburton, I ;

Hecht, S ;

Bacher, A ;

Eisenreich, W ;

Rohdich, F ;

Hunter, WN .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (50) :52753-52761

← 1 2 3 4 5 6 →