The use of bioisosteric groups in lead optimization

被引:58
作者
Chen, XQ
Wang, WB
机构
[1] Tularik Inc, San Francisco, CA 94080 USA
[2] Chiron Corp, Emeryville, CA 94608 USA
来源
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 38 | 2003年 / 38卷
关键词
D O I
10.1016/S0065-7743(03)38033-9
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:333 / 346
页数:14
相关论文
共 72 条
[41]   New generation dopaminergic agents.: Part 8:: Heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D2 template [J].
Mewshaw, RE ;
Zhao, RL ;
Shi, XJ ;
Marquis, K ;
Brennan, JA ;
Mazandaranai, H ;
Coupet, J ;
Andree, TH .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (03) :271-274
[42]  
Michaelides MR, 1999, CURR PHARM DESIGN, V5, P787
[43]  
Montana J, 2000, Curr Opin Drug Discov Devel, V3, P353
[44]  
NEWTON CL, 2003, Patent No. 0311222
[45]   Structure-activity relationships of a series of pyrrolo[3,2-d]pyrimidine derivatives and related compounds as neuropeptide Y5 receptor antagonists [J].
Norman, MH ;
Chen, N ;
Chen, ZD ;
Fotsch, C ;
Hale, C ;
Han, NH ;
Hurt, R ;
Jenkins, T ;
Kincaid, J ;
Liu, LB ;
Lu, YL ;
Moreno, O ;
Santora, VJ ;
Sonnenberg, JD ;
Karbon, W .
JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (22) :4288-4312
[46]  
Olesen P H, 2001, Curr Opin Drug Discov Devel, V4, P471
[47]   Inhibitors of inosine monophosphate dehydrogenase as potential chemotherapeutic agents [J].
Pankiewicz, KW .
EXPERT OPINION ON THERAPEUTIC PATENTS, 2001, 11 (07) :1161-1170
[48]   Aromatic quinolinecarboxamides as selective, orally active antibody production inhibitors for prevention of acute xenograft rejection [J].
Papageorgiou, C ;
von Matt, A ;
Joergensen, J ;
Andersen, E ;
Wagner, K ;
Beerli, C ;
Than, T ;
Borer, X ;
Florineth, A ;
Rihs, G ;
Schreier, MH ;
Weckbecker, G ;
Heusser, C .
JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (12) :1986-1992
[49]   Pyrazole bioisosteres of leflunomide as B-cell immunosuppressants for xenotransplantation and chronic rejection: Scope and limitations [J].
Papageorgiou, C ;
Albert, R ;
Floersheim, P ;
Lemaire, M ;
Bitch, F ;
Weber, HP ;
Andersen, E ;
Hungerford, V ;
Schreier, MH .
JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (18) :3530-3538
[50]  
PERNI RB, 2002, ANN D PROG MED CHEM, V39, P215